Scott Hanselman posted a little TikTok the other day that I saw via his Twitter (@shanselman). He encouraged people to make their mouse pointer bigger and turn it bright-ass green. I thought that was the silliest little thing, but I followed suit. I cannot believe I'm saying this, but it's making all the difference in the world.
In Win10, just search "Change Pointer Size" and open the applet that comes up. You can adjust the cursor to whatever size you want, and you can change the color right there. I just bumped it up to a size 2 and made the color the first high-vis green/yellow option. With the higher resolutions we normally use today on such big screens, this little change makes it so much easier to track across all those pixels.